Different Models Used to Induce Diabetes: a Comprehensive Review

Diabetes mellitus is a group of heterogeneous metabolic disorders. A large number of pharmacological agents and animal models are used in study of diabetes for understanding the pathogenesis, complications, genetic and environmental influences. Animal models for type 1 diabetes range from animals with spontaneously developing autoimmune diabetic to chemical ablation of the pancreatic beta cells and Type 2diabetes is studied in both obese and non-obese animal models with varying degrees of insulin resistance and beta cell failure. In recent years, a large number of new genetically modified animals, chemical agents, surgical manipulations, viruses and diabetogenic hormones have been engineered for the study of diabetes.